2,3,5,6-Tetrafluorobenzyl alcohol
2,3,5,6-Tetrafluorobenzyl alcohol
CAS: 4084-38-2
Molecular Formula: C7H4F4O
2,3,5,6-Tetrafluorobenzyl alcohol - Names and Identifiers
| Name | 2,3,5,6-Tetrafluorobenzyl alcohol |
| Synonyms | 2,3,5,6-Tetraf RARECHEM AL BD 0417 2,3,5,6-Tetrafluoro Benzyl Tetrafluoro Benzyl Alcohol 2,3,5,6-tetrafluorobenzylol 2,3,5,6-TETRAFLUOROBENYL ALCOHOL 2,3,5,6-TETRAFLUOROBENZYL ALCOHOL 2,3,5,6-Tetrafluorobenzyl alcohol 2,3,5,6-Tetrafluorobenzyl Methanol Benzenemethanol,2,3,5,6-tetrafluoro- (2,3,5,6-TETRAFLUORO-PHENYL)-METHANOL |
| CAS | 4084-38-2 |
| EINECS | 443-840-7 |
| InChI | InChI=1/C7H4F4O/c8-4-1-5(9)7(11)3(2-12)6(4)10/h1,12H,2H2 |
2,3,5,6-Tetrafluorobenzyl alcohol - Physico-chemical Properties
| Molecular Formula | C7H4F4O |
| Molar Mass | 180.1 |
| Density | 1.499 |
| Melting Point | 32-38 °C |
| Boling Point | 220-225 °C |
| Flash Point | 62 °C |
| Vapor Presure | 0.657mmHg at 25°C |
| Appearance | powder to lump to clear liquid |
| Color | White or Colorless to Light yellow |
| pKa | 12.94±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.456 |
| MDL | MFCD00792428 |
| Physical and Chemical Properties | White solid or colorless transparent liquid |
2,3,5,6-Tetrafluorobenzyl alcohol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| Hazard Class | IRRITANT |
2,3,5,6-Tetrafluorobenzyl alcohol - Reference Information
| overview | tetrafluorementhrin (transfluthrin) is a pyrethroid insecticide developed and produced by Bayer company in Germany in the 1980 s. it is mainly used for the control of sanitary pests and has the functions of fast hitting and killing. At present, few domestic manufacturers produce pyrethroid pesticides with great market prospects. 2,3,5, 6-tetrafluorobenzyl alcohol is an important intermediate for the synthesis of pyrethroid insecticide tetrafluorphrin. |
| preparation | weigh 20.5g pentafluorobenzonitrile, 0.2g 10% Pd/C (produced by Baoji ruike pharmaceutical and chemical co., ltd.),70mLTHF,9.5g acetic acid are added into a 250mL autoclave, nitrogen is used to replace the gas three times, H2 is passed to a pressure of 10atm, the temperature is raised to 55 ℃, after 10h of reaction, the raw materials are sampled and analyzed, and the raw materials disappear, the insoluble matter was filtered out, and the solvent was recovered under reduced pressure to obtain 25.6g acetate of pentafluorobenzene amine, content: 97.9%(HPLC), yield: 93.8%. Add 25.6g of acetate of pentafluorobenzylamine to 100g of water, slowly add 10.2g of concentrated sulfuric acid, keep the temperature at 55 ℃, drop 20g of 40% NaNO2 aqueous solution, use starch-potassium iodide test paper to detect the solution until the test paper turns blue, continue stirring for 1h, then raise the temperature to 85 ℃, hydrolyze for 6h, cool to room temperature, separate organic phase to recover solvent and dry to obtain 18.1g of pentafluorobenzyl methanol, with the content: 97.3%(GC), yield: 91.8%. Take 9.9g of pentafluorobenzene methanol into 30mL of methanol, raise the temperature to 50 ℃, add 5.1gZn powder in batches, slowly add 5.5g of concentrated hydrochloric acid dropwise, keep the reaction at 50 ℃ for 30h, detect by GC that the raw materials disappear, filter out the insoluble matter, extract with 2 × 25mL of dichloromethane, combine the organic phase, dry with anhydrous Na2SO4, evaporate the organic solvent at normal pressure, and then distill under reduced pressure, the fraction of 84~86 ℃/10.8mmHg was collected to obtain 8.0g of product, content: 99.0%(GC), yield: 88.8%,mp:34~36 ℃. |
| use | 2,3,5,6-tetrafluorobenzyl alcohol is an intermediate of the hygienic insecticide tetrafluorophenthrin. |
| production method | its preparation method is to add NaBH4 ethylene glycol dimethyl ether solution dropwise with 2,3,5,6-tetrafluorobenzoic acid in ethylene glycol dimethyl ether at a temperature of <30 ℃, stir for 30min, then react with ethylene glycol dimethyl ether solution of dimethyl sulfate at 50 ℃ for 1h, continue the reaction for 2h, and then post-process to obtain the product. |
Last Update：2024-04-09 21:04:16
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